Start

Activate the Detonator and wait for the Renegade, Weaver, Guardian or Daredevil to open a portal with White Mantle Portal Device (the rest of the group stacks Might in the vestibule) or if no one can skip just walk up to the Elite Flame Legion Fire Shaman. Kill him, /gg to reset your cooldowns and split up to disable the four colliders.

Repulsor lab room - South

This should be done by two people, but can be soloed (usually by Guardian) as shown in the video below. Learn the timing of the turret shots and jump or dodge over them. You can also take a Safety Shield from the beginning and use it to block shots for a short duration.

One person activates the console to the left 1 to grant the other person short access to the console at the right 2 .

Activating 2 enables short access to the two final consoles at 3 . You can bypass the Immobile from triggering them by standing exactly in the middle and pressing both buttons at the same time.

Researcher Dormitories - East

2 people (usually Renegade and Soulbeast) should do this area immediately after the Elite Flame Legion Fire Shaman. Remember to destroy the Unstable Portals as well. Finishing this event in time will grant you a 10% damage boost for the endboss.

Superheated Room - West

This is usually soloed by the Weaver but other classes can do it as well, like in the video shown below.

Subject 6 - Northwest

Gather at Subject 6 after finishing the other three colliders. During the fight, small and large (at 75%/50/25% health) Oozes will spawn and move toward it slowly, restoring its health when they reach it. Subject 6 also has a easily distinguishable Shield Form, hitting him then will give him stacks of Overload. Reaching 20 stacks results in a party wipe.

There are two main tactics for killing it:

Option 1 (easy): Everyone goes AFK until Subject 6 blocks for the first time. After the blocking is over, nuke him without killing any Oozes.
Requires high damage and you may have to wait a while as the blocking occurs at random times.

Option 2 (coordinated): The team nukes from the beginning ignoring the Oozes, but refrains from using crowd control effects and breaking his defiance bar. If Subject 6 starts blocking, immediately break the defiance bar using unblockable CC skills to bypass the Overload mechanic.

Thaumanova Anomaly

After all four colliders are disabled, use /gg to reset any cooldowns and resurrect directly at the Thaumanova Anomaly console. Activate it to teleport up and stack Might.
During the fight, try to stack as much as possible on one or two adjacent platforms but don’t die from Mistlock Instability: Social Awkwardness if it is present.

Alternate the special Hex Shield skill between players for her Gaze attack (the beam dissolving the platforms) and the Cosmic Instability debuff (occurring after 50% health). The Flux Bomb debuff will also cause nearby platforms to disappear.